Literally, inability to remain motionless. A side effect of certain psychiatric drugs that can be a mild sense of disquiet or anxiety (which may be easily overlooked) to a total inability to sit still, accompanied by overwhelming anxiety,
malaise, and severe
dysphoria (manifesting as an almost indescribable sense of terror and doom). - wikipedia
Often accompanied by dyskinesia, or
tremor.
Contrary to the other definition, it IS treatable.