Literally, when somebody's brain has stopped functioning such that they will never regain conciousness, hence coloquially somebody who is idiotic, dumb or clueless beyond belief. Similar to "too stupid to live".
Synonyms for braindead
On this page, you will find 30 slang terms related to braindead. Some of the top words include: claff, fuck head, kumquat, Wigglytuff, shate, and 25 more.