ludes

1 - Slang term for the drug methaqualude or simple quaaludes, a barbituate like Central Nervous depressant drug which causes clumsiness and fatigue, often used to treat insomnia and anxiety. 2 - "TO BE ON LUDES": Idiotical, Dull Minded, Dim-Witted, Stupid, Lacking intelligence, Feeble Minded.